Objectives
To systematically review the literature comparing the efficacy and safety of dexmedetomidine and midazolam when used for procedural sedation

Conclusions
Dexmedetomidine is a promising alternative to midazolam for use in procedural sedation.
Dexmedetomidine provides more comfort during the procedure for the patient and clinician.
If carefully titrated, the safety profiles are similar.

For complete research article